Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, PR China.
Thromb Res. 2012 Oct;130(4):e203-8. doi: 10.1016/j.thromres.2012.07.008. Epub 2012 Aug 1.
Toll like receptor 4 (TLR4) expression was found to increase markedly in human atherosclerotic lesions, notably on macrophages and endothelial cells. TLR4 Asp299Gly polymorphism was associated with a blunted receptor activity and a subsequently diminished inflammatory response, and may subsequently reduce atherosclerosis (AS) risk. However, the results of molecular epidemiological studies remained inconsistent.
The PubMed, CNKI databases were searched for all articles available. The OR corresponding to the 95% confidence interval (95% CI) was used to assess the association between TLR4 Asp299Gly polymorphism and risk of AS.
15 case-control studies with 9,989 cases and 6,746 controls were available for this analysis. For control subjects, G allele frequency of TLR4 Asp299Gly polymorphism was ranging from 0.045 to 0.085. The G allele and the AG/GG genotypes were not associated with significantly risk of AS (OR=1.02, 95% CI=0.83 - 1.26 for G versus A and OR=0.96, 95% CI=0.80 - 1.15 for AG/GG versus AA, respectively) by random effects model.
These findings indicated that TLR4 Asp299Gly polymorphism may not play a role in AS development.
研究发现，Toll 样受体 4（TLR4）在人类动脉粥样硬化病变中的表达明显增加，特别是在巨噬细胞和内皮细胞上。TLR4 Asp299Gly 多态性与受体活性降低和随后的炎症反应减弱有关，可能随后降低动脉粥样硬化（AS）的风险。然而，分子流行病学研究的结果仍然不一致。
在 PubMed、CNKI 数据库中搜索了所有可用的文章。使用比值比（OR）及其 95%置信区间（95%CI）来评估 TLR4 Asp299Gly 多态性与 AS 风险之间的关联。
这项分析纳入了 15 项病例对照研究，共 9989 例病例和 6746 例对照。对于对照人群，TLR4 Asp299Gly 多态性的 G 等位基因频率在 0.045 到 0.085 之间。G 等位基因和 AG/GG 基因型与 AS 的风险无显著相关性（G 对 A 的 OR=1.02，95%CI=0.83-1.26；AG/GG 对 AA 的 OR=0.96，95%CI=0.80-1.15，均采用随机效应模型）。
这些发现表明 TLR4 Asp299Gly 多态性可能与 AS 的发生无关。
