Telles-Correia Diogo
Serviço de Psiquiatria, Faculdade de Medicina de Lisboa, Unidade Transplantação, Hospital Curry Cabral, Lisboa, Portugal.
Acta Med Port. 2011 Dec;24 Suppl 4:835-44. Epub 2011 Dec 31.
One of the most common indications for Liver transplantation is Alcohol Liver Disease (ALD). Transplant recipients with ALD have a similar prognosis in terms of medical evolution and quality of life to those with other liver diseases. ALD is present when alcoholism (alcohol dependence /abuse) or heavy drinking coexists with chronic/acute liver disease. In the present article difficulties in establishing this diagnosis are debated. The main predictors of alcohol intake relapse after transplantation are: pre-transplantation abstinence (> 6m), social support, diagnosis acceptance, history of previous treatments, alcohol abuse VS dependence, Vaillant prognosis factors, good adherence (good prognosis); and family history of alcoholism, psychiatric history (psychosis, personality disorder), duration of alcoholism period, quantity of alcohol /day consumed (bad prognosis). Based in these factors we present a new evaluation scale. Diagnosis of alcohol relapse depends on the criterion used. Relapse rate is 5.6% /year. In the end of this article we discuss the different psychopharmacological and psychological methods used to treat pos-transplantation alcoholism relapse and some ethical aspects related to discrimination of patients with ALD.
肝移植最常见的指征之一是酒精性肝病(ALD)。患有ALD的移植受者在疾病进展和生活质量方面的预后与患有其他肝病的患者相似。当酗酒(酒精依赖/滥用)或大量饮酒与慢性/急性肝病并存时,即存在ALD。在本文中,对确立这一诊断的困难进行了讨论。移植后酒精摄入复发的主要预测因素包括:移植前戒酒(>6个月)、社会支持、对诊断的接受程度、既往治疗史、酒精滥用与依赖、瓦兰特预后因素、良好的依从性(预后良好);以及酗酒家族史、精神病史(精神病、人格障碍)、酗酒持续时间、每日饮酒量(预后不良)。基于这些因素,我们提出了一种新的评估量表。酒精复发的诊断取决于所采用的标准。复发率为每年5.6%。在本文结尾,我们讨论了用于治疗移植后酒精成瘾复发的不同心理药理学和心理学方法,以及与歧视ALD患者相关的一些伦理问题。