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[学校筛查项目中发现的泌尿系统异常患者的肾小球超微结构与预后]

[Glomerular ultrastructures and prognosis of the patients with urinary abnormalities found by school screening program].

作者信息

Yanase K, Kaneda K, Chiang Y Y, Takebayashi S

机构信息

Second Department of Pathology, Fukuoka University, Japan.

出版信息

Nihon Jinzo Gakkai Shi. 1990 Oct;32(10):1095-101.

PMID:2287101
Abstract

Detailed histopathological study were performed and compared with clinical features in 120 children with serial renal biopsies who were found by school screening program. 41 cases (34.2%) of IgA nephropathy (IgAN), 26 cases (21.7%) of thin membrane disease (TMD) and 22 cases (18.3%) of normal glomeruli [( Normal]) accounted for 74.2% of all biopsies. 81 cases (67.5%) were revealed to be minor glomerular abnormalities by light microscopy and which contained 26 cases (32.1%) of TMD, 22 cases (27.2%) of [Normal] and 19 cases (23.4%) of IgAN. The frequency and the severity of proteinuria was significantly higher in IgAN than in TMD and [Normal] (P less than 0.01, P less than 0.05). Hematuria was significantly greater in [Normal] than in IgAN. In the 71 follow-up cases, no patient went to renal insufficiency, moreover, urinary abnormalities had disappeared in 25.4% of the patients including IgAN, TMD, [Normal], nonIgA proliferative glomerulonephritis, incomplete foot process disease and MPGN. [Normal] consisted of stationary or exercised urinary abnormality.

摘要

对120名通过学校筛查项目发现的进行了系列肾活检的儿童进行了详细的组织病理学研究,并与临床特征进行了比较。41例(34.2%)IgA肾病(IgAN)、26例(21.7%)薄基底膜肾病(TMD)和22例(18.3%)肾小球正常([正常])占所有活检病例的74.2%。81例(67.5%)经光学显微镜检查显示为轻度肾小球异常,其中包括26例(32.1%)TMD、22例(27.2%)[正常]和19例(23.4%)IgAN。IgAN患者蛋白尿的频率和严重程度显著高于TMD和[正常]患者(P<0.01,P<0.05)。[正常]患者的血尿明显多于IgAN患者。在71例随访病例中,无患者发展为肾功能不全,此外,包括IgAN、TMD、[正常]、非IgA增殖性肾小球肾炎、不完全足突病和膜增生性肾小球肾炎在内的25.4%的患者尿液异常消失。[正常]包括静止性或运动性尿液异常。

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