Sharad Pawar College of Pharmacy, Wanadongri, Nagpur, India.
Drug Dev Ind Pharm. 2013 Aug;39(8):1247-53. doi: 10.3109/03639045.2012.710236. Epub 2012 Aug 8.
Applications of molecularly imprinted polymer (MIPs), is rapidly increasing, especially in the drug delivery field. Molecularly imprinted polymers are the molecular traps, which can entrap the specific molecule and also control its release. Polymer complexes were prepared with and without propranolol HCl as templates, MAA (methacrylic acid) as monomer and EGDMA (ethyleneglycol dimethacrylate) as crosslinker by solvent polymerization technique. Drug release pattern from these polymer complexes were compared and maximum drug release in 12 h was consider to optimize the ratio of MAA and EGDMA. Since, the maximum propranolol HCl release from polymer complex was low (62.15%) in optimized batch, inclusion complex of drug with β-cyclodextrin were prepared for the higher drug release (80.32%). The selected polymer complexes were treated with methanol for complete removal of the drug to form MIPs. These MIPs were reloaded with the drug and subjected for drug release. The release patterns from reloaded MIP's were observed to be slightly quicker than their corresponding MIP's.
分子印迹聚合物（MIPs）的应用正在迅速增加，特别是在药物输送领域。分子印迹聚合物是分子陷阱，可以捕获特定的分子并控制其释放。将 MAA（甲基丙烯酸）作为单体和 EGDMA（乙二醇二甲基丙烯酸酯）作为交联剂，通过溶剂聚合技术制备了含有和不含有盐酸普萘洛尔的聚合物配合物。比较了这些聚合物配合物的药物释放模式，并考虑优化 MAA 和 EGDMA 的比例以实现最大 12 小时的药物释放。由于在优化批次中从聚合物配合物中释放的盐酸普萘洛尔最大（62.15%），因此为了实现更高的药物释放，制备了药物与β-环糊精的包合物（80.32%）。将选定的聚合物配合物用甲醇处理以完全去除药物以形成 MIPs。将这些 MIPs 重新加载药物并进行药物释放。观察到重新加载 MIP 的释放模式比其相应的 MIP 稍微快一些。
