Koukouras D, Spyropoulos C, Zygomalas A, Tzoracoleftherakis E
Department of Surgery, University Hospital of Patras, Rion, Greece.
Eur J Gynaecol Oncol. 2012;33(3):255-6.
Mastectomy with axillary lymph node dissection (ALND) represents the gold standard in the treatment of male breast carcinoma. Recently, data have emerged supporting that sentinel lymph node biopsy (SNB) may be feasible in selected patients. The aim of this study was to analyze the safety and prognostic reliability of SNB in male patients with breast carcinoma and clinically negative axilla.
During a 10-year period (2000-2010), 11 men with mean age 66.1 years (range 34-84) diagnosed with breast carcinoma were retrospectively included to our study. All patients underwent SNB. Regardless of the SNB results, completion axillary clearance was conducted in all cases.
SNB detection rate was 100%, while the mean number of sentinel nodes removed was 1.5 +/- 0.7 (range 1-2). Frozen section analysis revealed a negative sentinel node in four out of 11 patients (36.4%). Independently of these results, all patients underwent completion ALND. The overall false-negative rate, defined as the percentage of all node-positive tumors in which the SNB was negative, was 0%.
The current study indicates that SNB may be feasible in selected male individuals with breast carcinoma. The technique may reduce the morbidity related to dissection of the axilla; prospective multicenter trials are needed in order to define the exact criteria for wider application of this technique.
乳房切除术加腋窝淋巴结清扫术（ALND）是男性乳腺癌治疗的金标准。最近，有数据表明前哨淋巴结活检（SNB）在部分患者中可能可行。本研究的目的是分析SNB在男性乳腺癌且腋窝临床阴性患者中的安全性和预后可靠性。
在10年期间（2000 - 2010年），对11例平均年龄66.1岁（范围34 - 84岁）诊断为乳腺癌的男性患者进行回顾性研究。所有患者均接受了SNB。无论SNB结果如何，所有病例均进行了腋窝清扫术。
SNB检出率为100%，而切除的前哨淋巴结平均数量为1.5±0.7（范围1 - 2）。冰冻切片分析显示11例患者中有4例（36.4%）前哨淋巴结为阴性。无论这些结果如何，所有患者均接受了腋窝清扫术。总体假阴性率，即SNB为阴性的所有淋巴结阳性肿瘤的百分比，为0%。
当前研究表明SNB在部分男性乳腺癌患者中可能可行。该技术可能降低与腋窝清扫相关的发病率；需要进行前瞻性多中心试验以确定该技术更广泛应用的确切标准。
