卡麦角林在使用非典型抗精神病药物治疗的垂体泌乳素引起症状患者管理中的安全性。
Safety of cabergoline in the management of pituitary prolactin-induced symptoms with patients treated with atypical neuroleptics.
作者信息
Coronas Ramón, Cobo Jesús, Giménez-Palop Olga, Ortega Emilio, Márquez Manel
机构信息
Department of Psychiatry, Corporació Sanitária i Universitária Parc Taulí, Sabadell, Barcelona, Spain.
出版信息
Curr Drug Saf. 2012 Apr;7(2):92-8. doi: 10.2174/157488612802715753.
UNLABELLED
Atypical antipsychotic-induced hyperprolactinemia can cause important clinical symptoms, particularly in young women and also in men, such as impotence, loss of libido, gynecomastia, anovulation and galactorrhea.
METHODS
Observational over one-year follow-up of six patients (four women and two men, mean age of 31.1 years, range 26-37), treated with different atypical antipsychotics in an outpatient psychiatric device, who had clinical complications associated to high prolactin serum levels. All of them were treated with standard doses of cabergoline.
RESULTS
Most patients experienced significant clinical improvement after treatment with standard doses of cabergoline (mean dosage 1.08 mg/week), maintained for a mean of 18 month. Normal prolactin levels were achieved after the first months of treatment with cabergoline. No side effects or worsening of psychotic or behavioral symptoms were observed.
CONCLUSIONS
Long-term treatment with cabergoline seems to be safe in atypical antipsychotic-treated patients.
未标注
非典型抗精神病药物引起的高催乳素血症可导致重要的临床症状，尤其是在年轻女性以及男性中，如阳痿、性欲减退、男子女性型乳房、无排卵和溢乳。
方法
对6例患者（4名女性和2名男性，平均年龄31.1岁，范围26 - 37岁）进行为期一年的观察随访，这些患者在门诊精神科接受不同的非典型抗精神病药物治疗，且出现了与血清催乳素水平升高相关的临床并发症。他们均接受标准剂量的卡麦角林治疗。
结果
大多数患者在接受标准剂量的卡麦角林（平均剂量1.08毫克/周）治疗后，临床症状有显著改善，治疗平均持续18个月。在使用卡麦角林治疗的最初几个月后，催乳素水平恢复正常。未观察到副作用或精神病性或行为症状的恶化。
结论
对于接受非典型抗精神病药物治疗的患者，长期使用卡麦角林似乎是安全的。
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