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多长度或 24 厘米输尿管支架?使用经过验证的问卷对支架相关症状进行的多中心随机比较。

Multi-length or 24 cm ureteric stent? A multicentre randomised comparison of stent-related symptoms using a validated questionnaire.

机构信息

Departments of Urology, Royal Liverpool and Broadgreen Hospitals, Liverpool, UK.

出版信息

BJU Int. 2013 Jun;111(7):1099-104. doi: 10.1111/j.1464-410X.2012.11388.x. Epub 2012 Aug 9.

Abstract

UNLABELLED

WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: One of the suggested factors for stent-related symptoms is that excess distal intravesical stent mass may cause bladder irritation. There is a lack of studies investigating this in a randomised controlled fashion using a validated questionnaire. This study compared two of the most commonly used length of stents (a 30 cm multi-length vs a 24 cm long stent) and showed no significance difference in stent-related symptoms in patients with either of these stents.

OBJECTIVE

To investigate whether excessive redundant intravesical stent component contributes to the severity of stent-related symptoms in patients with a ureteric stent. We compared stent-related symptoms in patients who had either a standard 24 cm or multi-length ureteric stent.

PATIENTS AND METHODS

In all, 162 patients with upper urinary tract calculi requiring ureteric stent insertion were randomised to receive either a 6 F × 24 cm Contour(TM) or multi-length 6 F × 22-30 cm Contour VL(TM) stent. Patients were requested to complete the validated Bristol Ureteric Stent Symptom Questionnaire (USSQ) at 1 and 4 weeks after stent insertion and 4 weeks after removal. The mean scores for each domain of the USSQ for both groups were compared using the Student's t-test. Any adverse events, e.g. stent migration, early removal of stent due to stent-related symptoms and failure of stent insertion, were also recorded.

RESULTS

In all, 153 patients who had successful stent insertion were requested to complete the USSQ and 74% of patients returned at least the week 1 questionnaire. At 1 and 4 weeks with the stent in situ, comparison of the mean scores showed no significant difference in urinary symptoms, pain, general health, work performance, sexual dysfunction and number of days patients stayed in bed or reduced their routine activities. Three (2%) patients had their stent removed early due to stent-related symptoms and five (3%) had failed stent insertion.

CONCLUSIONS

This study did not find any difference in symptoms between the 24 cm or multi-length Contour stents. However, the study was not powered to detect small differences particularly for the pain symptom domain. Stents should only be used sparingly and the stent dwell-time should be minimised.

摘要

目的

研究过长的膀胱内留置支架部分是否会加重留置输尿管支架患者的支架相关症状。我们比较了使用标准的 24cm 长支架与使用多长度的 22-30cm 长 Contour VL 支架的患者之间的支架相关症状。

方法

共纳入 162 例需留置输尿管支架的上尿路结石患者,随机分为 6F×24cm Contour(TM)支架组和 6F×22-30cm Contour VL(TM)多长度支架组。患者在留置支架后 1 周和 4 周以及取出支架后 4 周时填写 Bristol 输尿管支架症状问卷(Ureteric Stent Symptom Questionnaire,USSQ)。使用学生 t 检验比较两组患者 USSQ 各维度的平均评分。记录所有不良事件,如支架移位、因支架相关症状而提前取出支架、以及支架置入失败等。

结果

共 153 例患者成功留置支架并填写 USSQ,74%的患者至少在第 1 周时完成了问卷。在支架留置时的第 1 周和第 4 周,两组患者的平均评分在尿症状、疼痛、总体健康、工作表现、性功能障碍以及需要卧床或减少日常活动的天数方面均无显著差异。3 例(2%)患者因支架相关症状而提前取出支架,5 例(3%)患者支架置入失败。

结论

本研究未发现 24cm 长支架与多长度 Contour 支架之间在症状方面存在差异。然而,本研究没有足够的能力来检测小的差异,尤其是疼痛症状方面。支架应尽量少用,支架留置时间应尽量缩短。

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