泛素、SUMO 和磷酸基团：三种翻译后修饰物如何控制蛋白质命运。
Ubiquitin, SUMO, and phosphate: how a trio of posttranslational modifiers governs protein fate.
机构信息
Cancer Research UK London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms EN6 3LD, UK.
出版信息
Mol Cell. 2012 Aug 10;47(3):335-7. doi: 10.1016/j.molcel.2012.07.016.
PMID:22883623
Abstract
In this issue of Molecular Cell, Guo et al. (2012) demonstrate how a series of sequential posttranslational modifications, phosphorylation, sumoylation, and ubiquitylation, cooperate to target human flap endonuclease FEN1 to degradation by the proteasome at the end of S phase.
摘要
在本期《分子细胞》中，郭等人（2012）展示了一系列连续的翻译后修饰（磷酸化、SUMO 化和泛素化）如何协同作用，将人类的核酸内切酶 FEN1 靶向到 S 期结束时的蛋白酶体降解。
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