Baumgarten R, Müller R, Markus R, Hintsche-Kilger B, Fengler J D, Meisel H
Infektionsklinik des Städtischen Krankenhauses Berlin-Prenzlauer Berg, Berlin, DDR.
Gastroenterol J. 1990;50(3):124-8.
A total of 58 patients with histologically confirmed chronic viral hepatitis B and presence of HBsAg and HBV-DNA in the serum were randomized in a prospectively controlled trial. 30 patients were treated with 3 megaunits of rIFN a-2b s.c. thrice weekly for 4 months. 28 controls received no treatment. The post-treatment follow-up period consisted of 6 months. 28 patients treated and 27 controls completed the protocol. One female patient of the treatment group showed a complete response (loss of HBsAg, HBeAg and HBV-DNA), 8 other patients (32%) revealed a partial response to therapy (loss of HBeAg and HBV-DNA). Three patients of the control-group (11%) lost HBeAg and HBV-DNA spontaneously. This finding is statistically significant (p less than 0.05). The elimination of HBV-markers from the serum was associated with a normalization of aminotransferase activities in the serum. A reactivation of hepatitis was not observed after seroconversion.
在一项前瞻性对照试验中，共有58例经组织学确诊为慢性乙型病毒性肝炎且血清中存在乙肝表面抗原（HBsAg）和乙肝病毒脱氧核糖核酸（HBV-DNA）的患者被随机分组。30例患者接受皮下注射3百万单位重组干扰素α-2b治疗，每周3次，共4个月。28例对照患者未接受治疗。治疗后的随访期为6个月。28例接受治疗的患者和27例对照患者完成了方案。治疗组的1例女性患者出现完全应答（乙肝表面抗原、乙肝e抗原和乙肝病毒脱氧核糖核酸消失），其他8例患者（32%）显示对治疗有部分应答（乙肝e抗原和乙肝病毒脱氧核糖核酸消失）。对照组的3例患者（11%）自发出现乙肝e抗原和乙肝病毒脱氧核糖核酸消失。这一发现具有统计学意义（p小于0.05）。血清中乙肝病毒标志物的消除与血清中氨基转移酶活性的正常化相关。血清学转换后未观察到肝炎复发。
