噻嗪类和噻嗪样利尿剂：降低晚期肾病患者血压的机会。
Thiazide and thiazide-like diuretics: an opportunity to reduce blood pressure in patients with advanced kidney disease.
机构信息
Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
出版信息
Curr Hypertens Rep. 2012 Oct;14(5):416-20. doi: 10.1007/s11906-012-0293-4.
Thiazide and thiazide-like diuretics have been widely used as blood pressure-lowering agents for more than 5 decades. However, their use in patients with advanced chronic kidney disease has been limited and often discouraged. The exact mechanism of how thiazide and thiazide-like diuretics lower blood pressures is still in question. Emerging evidence suggests that thiazides and thiazide-like diuretics are effective as blood pressure-lowering drugs in patients with advanced chronic kidney disease. Review of the literature suggests that physicians should not discard thiazide and thiazide-like diuretics as options for blood pressure management in patients with chronic advanced kidney disease.
噻嗪类和噻嗪样利尿剂作为降压药已经广泛应用超过 50 年。然而，在晚期慢性肾脏病患者中的应用受到限制，通常不被鼓励。噻嗪类和噻嗪样利尿剂降低血压的确切机制仍存在疑问。新出现的证据表明，噻嗪类和噻嗪样利尿剂在晚期慢性肾脏病患者中作为降压药物是有效的。文献复习提示，医生不应摒弃噻嗪类和噻嗪样利尿剂作为慢性晚期肾脏病患者血压管理的选择。
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