Laboratory of Functional and Biomedical Nanomaterials, College of Materials Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, People's Republic of China.
J Biomed Mater Res A. 2013 Feb;101(2):607-12. doi: 10.1002/jbm.a.34343. Epub 2012 Aug 10.
Magnetite (Fe(3) O(4) ) nanoparticles with the surface hydroxyl groups were achieved by a polyol process. Using 2-(4-chlorosulfonylphenyl) ethyltrichlorosilane (CTCS) as initiator, 2-(methacryloyloxy)ethyl phosphorylcholine (MPC) as monomer, poly(2-(methacryloyloxy)ethyl phosphorylcholine) (PMPC)-grafted Fe(3) O(4) nanoparticles (MNP) were successfully prepared via the atom transfer radical polymerization (ATRP) method. The successful grafting of PMPC on the Fe(3) O(4) nanoparticles surface was ascertained from the FTIR analysis. The modified nanoparticles (MNP-CTCS-PMPC) showed a good biocompatibility in the cytotoxicity test in vitro. Performance testing of MNP-CTCS-PMPC was performed through magnetic resonance analysis (MR), and its r(2) /r(1) value was 24.1. These results indicated that the modified Fe(3) O(4) nanoparticles would be a potential MRI contrast reagent.
通过多元醇法制备了具有表面羟基的磁铁矿（Fe3O4）纳米粒子。以 2-（4-氯磺酰基苯基）乙基三氯硅烷（CTCS）为引发剂，以 2-（甲基丙烯酰氧基）乙基磷酸胆碱（MPC）为单体，通过原子转移自由基聚合（ATRP）法成功制备了聚（2-（甲基丙烯酰氧基）乙基磷酸胆碱）（PMPC）接枝的 Fe3O4 纳米粒子（MNP）。从 FTIR 分析证实了 PMPC 成功接枝到 Fe3O4 纳米粒子表面。体外细胞毒性试验表明，修饰后的纳米粒子（MNP-CTCS-PMPC）具有良好的生物相容性。通过磁共振分析（MR）对 MNP-CTCS-PMPC 的性能进行了测试，其 r2/r1 值为 24.1。这些结果表明，修饰后的 Fe3O4 纳米粒子将成为一种有潜力的 MRI 对比试剂。
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