评估术中放疗在乳腺癌现代治疗管理中的作用。

Evaluating the role of intra-operative radiation therapy in the modern management of breast cancer.

机构信息

Breast Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 300 E. 66th St., New York, NY 10065, USA.

出版信息

Surg Oncol. 2012 Dec;21(4):e159-63. doi: 10.1016/j.suronc.2012.06.003. Epub 2012 Aug 11.

DOI:10.1016/j.suronc.2012.06.003

PMID:22889742

Abstract

Over the last 10 years, intra-operative radiotherapy (IORT) has been used extensively in the clinical trial setting but has yet to make a significant clinical impact on current breast cancer management strategies. This review discusses the rationale behind IORT, the benefits and limitations of this technique over conventional whole breast radiation (WBRT), and the indications, contraindications, and appropriate patient selection criteria. In addition, the most up-to-date trial data and the role of IORT in future breast cancer management strategies are discussed.

摘要

在过去的 10 年中，术中放射治疗（IORT）在临床试验中得到了广泛应用，但尚未对当前乳腺癌管理策略产生重大的临床影响。本文讨论了 IORT 的基本原理、该技术相对于常规全乳放射治疗（WBRT）的优势和局限性，以及其适应证、禁忌证和合适的患者选择标准。此外，还讨论了最新的临床试验数据以及 IORT 在未来乳腺癌管理策略中的作用。