Scantamburlo G, Scheen A J
Université de Liège, Chef de Clinique, Service de Psychiatrie et Unité de Psychoneuroendocrinologie, CHU de Liège, Belgique.
Rev Med Liege. 2012 May-Jun;67(5-6):234-42.
Complex diseases are chronic diseases where the interrelations between genetic predisposition and environmental factors play an essential role in the arisen and the maintenance of the pathology. Upon psychological stress, the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system are activated resulting in release of glucocorticoids and catecholamines. Chronic stress may induce complex diseases where alterations of nervous, endocrine and immune systems are involved. Thus, chronic stress is more likely to induce a range of effects, depending on the capacity of the subject to cope with stress. CRH ("Corticotropin Releasing Hormone") is a key factor in the stress-immunity relationship. In this article, we propose an overview of the interrelations between central nervous, endocrine and immune systems and implications for health and diseases. The objective for the clinician is to propose therapeutic strategies targeting changes in human behaviour to cope with a potentially stressful environment.
复杂疾病是一类慢性疾病，其中遗传易感性与环境因素之间的相互关系在疾病的发生和维持过程中起着至关重要的作用。在心理应激状态下，下丘脑 - 垂体 - 肾上腺轴和交感神经系统被激活，导致糖皮质激素和儿茶酚胺的释放。慢性应激可能诱发涉及神经、内分泌和免疫系统改变的复杂疾病。因此，慢性应激更有可能引发一系列影响，这取决于个体应对压力的能力。促肾上腺皮质激素释放激素（CRH）是应激与免疫关系中的关键因素。在本文中，我们概述了中枢神经、内分泌和免疫系统之间的相互关系及其对健康和疾病的影响。临床医生的目标是提出针对人类行为变化的治疗策略，以应对潜在的压力环境。
