King's College Hospital, Denmark Hill, London, UK.
Br J Clin Pharmacol. 2013 Apr;75(4):951-4. doi: 10.1111/j.1365-2125.2012.04427.x.
Early trials in the field of hypertension focused on adults in their fifties and sixties. However, with the passage of time, a progressive effort has been made to expand the evidence base for treatment in older adults. 2008 saw publication of data from the Hypertension in the Very Elderly Trial which demonstrated significant mortality and morbidity benefits from antihypertensive therapy in octogenarians. More recently, additional data from this cohort has been published suggesting that appropriate anti-hypertensive therapy may lead to a reduction in incident cognitive impairment and fractures, whilst a 1 year open label extension of the main study confirmed many of the original trial findings. This review provides an overview of the Hypertension in the Very Elderly Trial whilst also discursively evaluating the latest data.
早期的高血压领域临床试验主要集中在五十多岁和六十多岁的成年人身上。然而，随着时间的推移，人们一直在努力扩大治疗老年人的证据基础。2008 年发表的数据来自于非常高龄老年人高血压试验（Hypertension in the Very Elderly Trial），该试验表明降压治疗在 80 岁以上人群中具有显著的死亡率和发病率益处。最近，该队列的其他数据也已发表，表明适当的抗高血压治疗可能会减少认知障碍和骨折的发生，而主要研究的 1 年开放标签扩展证实了许多原始试验结果。本综述概述了非常高龄老年人高血压试验，同时也对最新数据进行了论述性评估。
