Department of Chemistry, School of Sciences, Wuhan University of Technology, Wuhan 430070, PR China.
Inorg Chem. 2012 Sep 3;51(17):9208-13. doi: 10.1021/ic300473u. Epub 2012 Aug 16.
The synthesis of water-soluble and low-cytotoxicity quantum dots (QDs) in aqueous solution has received much attention recently. A one-step and convenient method has been developed for synthesis of water-soluble glutathione (GSH)-capped and Zn(2+)-doped CdTe QDs via a refluxing route. Because of the addition of Zn ions and the epitaxial growth of a CdS layer, the prepared QDs exhibit superior properties, including strong fluorescence, minimal cytotoxicity, and enhanced biocompatibility. The optical properties of QDs are characterized by UV-vis and fluorescence (FL) spectra. The structure of QDs was verified by transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectrometry (XPS), energy dispersive spectroscopy (EDS), atomic absorption spectrometry (AAS), and Fourier transform infrared spectroscopy (FTIR). Furthermore, the low cytotoxicity of the prepared QDs was proved by the microcalorimetric technique and inductively coupled plasma-atomic emission spectrometry (ICP-AES).
最近，人们对在水溶液中合成水溶性和低细胞毒性量子点（QD）产生了浓厚的兴趣。通过回流法，开发了一种一步法、简便的方法来合成水溶性谷胱甘肽（GSH）封端和 Zn（2+）掺杂的 CdTe QD。由于 Zn 离子的加入和 CdS 层的外延生长，所制备的 QD 表现出优异的性能，包括强荧光、最小细胞毒性和增强的生物相容性。QD 的光学性质通过紫外-可见和荧光（FL）光谱进行表征。通过透射电子显微镜（TEM）、X 射线衍射（XRD）、X 射线光电子能谱（XPS）、能谱（EDS）、原子吸收光谱（AAS）和傅里叶变换红外光谱（FTIR）验证了 QD 的结构。此外，通过微量热技术和电感耦合等离子体原子发射光谱（ICP-AES）证明了所制备的 QD 的低细胞毒性。
