Faculty of Pharmacy, Osaka Ohtani University, Nishikiori-Kita 3-11-1, Tondabayashi, Osaka 584-8540, Japan.
Org Lett. 2012 Sep 7;14(17):4406-9. doi: 10.1021/ol301901e. Epub 2012 Aug 16.
A small molecular model compound for the green fluorescent protein chromophore was readily synthesized by a novel condensation reaction of (thio)imidate with imino-ester via an aziridine intermediate. This compound showed fluorescence in the solid and frozen solution states but not in the solution state. Its fluorescent property was successfully applied in the detection of dsDNA.
一种小分子模型化合物，用于绿色荧光蛋白发色团，通过氮丙啶中间体，通过（硫）亚氨酸酯与亚氨基酯的新型缩合反应，很容易合成。该化合物在固态和冷冻溶液状态下显示荧光，但在溶液状态下不显示荧光。其荧光性质成功地应用于双链 DNA 的检测。
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