Chavatte-Palmer P, Tarrade A, Lévy R
Inra, UMR 1198 biologie du développement et reproduction, domaine de Vilvert, bâtiment 231, 78352 Jouy-en-Josas cedex, France.
Gynecol Obstet Fertil. 2012 Sep;40(9):517-9. doi: 10.1016/j.gyobfe.2012.07.010. Epub 2012 Aug 14.
Many epidemiological studies indicate that environmental conditions during embryonic and fetal development can have an impact on health at adulthood. Animal studies clearly demonstrate that maternal, and even paternal undernutrition or nutritional excess durably modify some epigenetic marks in their offspring, affecting gene expression and physiological adaptations to the environment. It is crucial to better define the effects of early environment on adult phenotype and epigenetic marks in humans and to develop, with the help of animal models, new preventive strategies and treatments.
许多流行病学研究表明，胚胎和胎儿发育期间的环境状况会对成年后的健康产生影响。动物研究清楚地表明，母体甚至父体的营养不足或营养过剩会持久地改变其后代的一些表观遗传标记，影响基因表达和对环境的生理适应。更好地确定早期环境对人类成年表型和表观遗传标记的影响，并借助动物模型开发新的预防策略和治疗方法至关重要。
