Department of Urology, Loyola University Medical Center, Maywood, IL 60153, USA.
Urology. 2012 Oct;80(4):e35-6. doi: 10.1016/j.urology.2012.06.031. Epub 2012 Aug 15.
Primary testicular germ cell tumors typically present with painless testis enlargement and have a propensity to spread to the retroperitoneal lymphatics. Delays in seeking treatment are unfortunately common and may lead to metastatic spread. Pure seminomas are the most commonly seen on histology and are not associated with elevations in serum alpha-fetoprotein. Mild elevations in alpha-fetoprotein in the setting of a pure seminoma may be due to unrecognized nonseminomatous elements and rarely other benign etiologies. We present the case of a 42-year-old man with a large 31 cm stage I pure seminoma and mildly elevated alpha-fetoprotein level at presentation.
原发性睾丸生殖细胞肿瘤通常表现为无痛性睾丸增大,并倾向于向腹膜后淋巴管扩散。不幸的是,人们往往会延迟寻求治疗,这可能导致转移扩散。组织学上最常见的是单纯精原细胞瘤,且与血清甲胎蛋白升高无关。在单纯精原细胞瘤的情况下,甲胎蛋白的轻度升高可能是由于未被识别的非精原细胞瘤成分引起的,罕见情况下也可能是其他良性病因所致。我们报告了一例 42 岁男性,其患有 31cm 大的 I 期单纯精原细胞瘤,且在就诊时甲胎蛋白水平轻度升高。