Centre for Pain Research, The University of Bath, Bath BA2 7AY, UK Department of Experimental-Clinical and Health Psychology, Ghent University, Ghent, Belgium.
Pain. 2013 Feb;154(2):190-199. doi: 10.1016/j.pain.2012.07.016. Epub 2012 Aug 15.
Methods for investigating human pain have been developed over the last 100years. Typically, researchers focus on people with clinical pain, or on healthy participants undergoing laboratory-controlled pain-induction techniques focussed mostly on exogenously generated skin nociception. Less commonly investigated are acute pain experiences that emerge naturally. Six common painful complaints were identified: headache, muscular pain, visceral pain, menstrual pain, dental pain, and pain associated with upper respiratory tract infection. Methods used to recruit participants with the natural occurrence of each pain complaint were identified, and features of their use reviewed. Also reviewed were experimental analogues designed to mimic these pains, with the exception of menstrual pain. Headache and menstrual pain appear to be most effectively researched in their naturally occurring form, whereas muscle and dental pain may be more easily induced. Upper respiratory tract infection and abdominal pain provide further challenges for researchers. Summary guidance is offered, and directions for methods development outlined.
在过去的 100 年中，已经开发出了用于研究人类疼痛的方法。通常，研究人员关注的是有临床疼痛的人群，或者是接受实验室控制的疼痛诱导技术的健康参与者，这些技术主要集中在外源性产生的皮肤伤害感受上。较少研究的是自然出现的急性疼痛体验。确定了六种常见的疼痛主诉：头痛、肌肉疼痛、内脏疼痛、月经疼痛、牙痛和上呼吸道感染相关疼痛。确定了招募每种疼痛主诉自然发生的参与者的方法，并回顾了其使用的特点。还回顾了旨在模拟这些疼痛的实验模拟，月经疼痛除外。头痛和月经疼痛似乎最适合以其自然形式进行研究，而肌肉和牙痛可能更容易诱发。上呼吸道感染和腹痛给研究人员带来了进一步的挑战。提供了总结性指导，并概述了方法开发的方向。
