Department of Medical Microbiology, Medical and Health Science Centre, University of Debrecen, Nagyerdei krt. 98, H-4032 Debrecen, Hungary.
J Clin Virol. 2012 Nov;55(3):262-5. doi: 10.1016/j.jcv.2012.07.009. Epub 2012 Aug 17.
Immunosuppression due to pregnancy may lead to higher susceptibility to infections and reactivation of latent infections, such as BK polyomavirus (BKPyV). There is lack of information about the prevalence of novel human polyomavirus 9 (HPyV9), WU (WUPyV) and KI (KIPyV) during pregnancy.
To study whether pregnancy results in higher prevalence of HPyV9, WUPyV, KIPyV and their correlation with BKPyV.
Plasma, urine and throat swab samples from 100 pregnant and 100 non pregnant women were screened for the presence of WUPyV, KIPyV, HPyV9 and BKPyV by PCR.
No WUPyV DNA was detected in plasma, urine and respiratory samples from pregnant and non pregnant women. KIPyV DNA was found in two plasma samples from non pregnant women (2%) and not detected in other samples from neither pregnant nor non pregnant women. HPyV9 DNA was determined in all sample types of pregnant and non pregnant women, respectively. There were no significant differences between pregnant and non pregnant women in HPyV9 DNA frequencies for plasma (2% vs. 6%), urine (3% vs. 2%) and respiratory samples (2% vs. 2%). Prevalence of BKPyV in urine samples was significantly higher (p=0.039) in pregnant women (13%) then in non pregnant women (4%); co infection with KIPyV and/or HPyV9 was not detected.
In contrast with BKPyV, infection with WUPyV, KIPyV and HPyV9 was not detected more frequently during pregnancy. To the best of our knowledge HPyV9 was detected first in respiratory samples in our study.
妊娠导致的免疫抑制可能会导致机体更容易感染潜伏性感染，如 BK 多瘤病毒（BKPyV）。目前关于新型人类多瘤病毒 9（HPyV9）、WU（WUPyV）和 KI（KIPyV）在妊娠期间的流行情况，我们知之甚少。
研究妊娠是否会导致 HPyV9、WUPyV、KIPyV 的流行率更高，以及它们与 BKPyV 的相关性。
采用 PCR 法对 100 例孕妇和 100 例非孕妇的血浆、尿液和咽拭子样本进行 WUPyV、KIPyV、HPyV9 和 BKPyV 的检测。
在孕妇和非孕妇的血浆、尿液和呼吸道样本中均未检测到 WUPyV DNA。KIPyV DNA 仅在 2 例非孕妇的血浆样本中检出（2%），在其他孕妇和非孕妇的样本中均未检出。HPyV9 DNA 存在于所有孕妇和非孕妇的样本类型中。孕妇和非孕妇的血浆（2%比 6%）、尿液（3%比 2%）和呼吸道样本（2%比 2%）中 HPyV9 DNA 的频率无显著差异。孕妇尿液标本 BKPyV 的检出率（13%）明显高于非孕妇（4%）（p=0.039）；未检出 KIPyV 和/或 HPyV9 共感染。
与 BKPyV 不同，妊娠时未检测到 WUPyV、KIPyV 和 HPyV9 的感染更频繁。据我们所知，在本研究中首次在呼吸道样本中检测到 HPyV9。
