[Study of in vitro thromboxane A2 generation by platelets of patients with first-time appearing angina pectoris under the effect of fish diet].

Thromboxane A2 (TxA2) is a pathogenic factor as it stimulates thrombogenesis and causes vasospastic reactions typical of coronary heart disease. The eicosapentaenic acid (EPA)-rich diet containing precursors of inactive TxA2 synthesis and the routine hospital diet (No. 10 according to Pevzner) were examined for effects on platelet generation of TxA2 on induction of ADP aggregation in 12 patients with first angina (FA). In patients with FA keeping diet No. 10, the platelets were found to be able to generate TxA2 under the influence of ADP, while in those on EPA-rich diet, the latter failed to exhibit this capacity. It was suggested that the EPA-containing fish diet might affect platelet aggregation favourably, which followed from the evidence for decreased pathogenic TxA2 generation in the aggregated platelets from FA patients and a lower risk of vascular spasms.