Howard Hughes Medical Institute, Section of Molecular, Cell and Developmental Biology, University of Texas, Austin, Texas 78712, USA.
Annu Rev Cell Dev Biol. 2012;28:627-53. doi: 10.1146/annurev-cellbio-092910-154208. Epub 2012 Aug 16.
Planar cell polarity (PCP), the orientation and alignment of cells within a sheet, is a ubiquitous cellular property that is commonly governed by the conserved set of proteins encoded by so-called PCP genes. The PCP proteins coordinate developmental signaling cues with individual cell behaviors in a wildly diverse array of tissues. Consequently, disruptions of PCP protein functions are linked to defects in axis elongation, inner ear patterning, neural tube closure, directed ciliary beating, and left/right patterning, to name only a few. This review attempts to synthesize what is known about PCP and the PCP proteins in vertebrate animals, with a particular focus on the mechanisms by which individual cells respond to PCP cues in order to execute specific cellular behaviors.
平面细胞极性 (PCP)，即细胞在一个平面内的定向和排列，是一种普遍存在的细胞特性，通常由所谓的 PCP 基因编码的一组保守蛋白所调控。PCP 蛋白将发育信号与单个细胞行为在各种组织中进行协调。因此，PCP 蛋白功能的破坏与轴伸长、内耳模式形成、神经管闭合、定向纤毛运动和左右模式形成等缺陷有关。本综述试图综合已知的 PCP 以及脊椎动物中的 PCP 蛋白，特别关注单个细胞如何响应 PCP 信号来执行特定的细胞行为的机制。
