Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.
Curr Opin Organ Transplant. 2012 Oct;17(5):485-9. doi: 10.1097/MOT.0b013e328357d8ba.
Re-transplantation of the lung has come of age. Here, we wish to review the recent literature on the topic and discuss clinical implications.
Many large volume transplant centres routinely perform lung re-transplantation with satisfactory outcomes. The main indication is bronchiolitis obliterans syndrome, that is chronic rejection of a previous lung transplant. Other indications, such as primary graft failure or early airway complications, are regarded with more caution, as outcomes compare less favourably with those following primary transplantation.
Re-transplantation of the lung can be performed safely and with outcomes rivalling those of primary transplants in carefully selected recipients with chronic rejection of a previous transplant.
肺再移植已经成熟。在此,我们希望对该主题的最新文献进行回顾并讨论其临床意义。
许多大容量移植中心常规进行肺再移植,效果令人满意。主要适应证是闭塞性细支气管炎综合征,即先前肺移植的慢性排斥反应。其他适应证,如原发性移植物失功或早期气道并发症,则需要更加谨慎,因为其结果与原发性移植相比不太理想。
对于先前移植发生慢性排斥的精心选择的患者,肺再移植是安全的,其结果可与原发性移植媲美。