Shvo 催化剂作用下的内酰胺、恶唑烷酮和咪唑烷酮与醛的直接 N-酰化反应。

Direct N-acylation of lactams, oxazolidinones, and imidazolidinones with aldehydes by Shvo's catalyst.

机构信息

Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.

出版信息

Org Lett. 2012 Sep 7;14(17):4646-9. doi: 10.1021/ol302087z. Epub 2012 Aug 22.

DOI:10.1021/ol302087z

PMID:22913512

Abstract

Direct N-acylation of lactams, oxazolidinones, and imidazolidinones was achieved with aldehydes by Shvo's catalyst without using any other stoichiometric reagent. The N-acylations with α,β-unsaturated aldehydes were achieved with excellent yields.

摘要

Shvo 催化剂可实现内酰胺、恶唑烷酮和咪唑烷酮与醛的直接 N-酰化，无需使用任何其他化学计量试剂。α,β-不饱和醛的 N-酰化反应可获得优异的产率。