结肠镜检查后发生肾皮质坏死。
Renal cortical necrosis following a colonoscopy.
作者信息
Hammadah Muhammad, Gaber Lillian, Raghavan Rajeev
机构信息
Department of Medicine, University of Aleppo, Aleppo, Syria.
出版信息
Clin Nephrol. 2013 Jan;79(1):67-71. doi: 10.5414/CN107171.
A 76-year old African-American male presented with profound renal failure within 2 weeks after a screening colonoscopy. Polyethylene glycol (PEG) was the sole oral preparatory agent. The significantly elevated lactate dehydrogenase (LDH) and biopsy findings were consistent with acute renal cortical necrosis (RCN). PEG is associated with AKI, but the exact mechanism is uncertain. PEG can be biodegraded to diethylene glycol (DEG), which is a nephrotoxic agent associated with RCN. Three months after presentation, the patient remains hemodialysis dependent.
一名76岁的非裔美国男性在结肠镜筛查后2周内出现严重肾衰竭。聚乙二醇（PEG）是唯一的口服肠道准备剂。乳酸脱氢酶（LDH）显著升高以及活检结果与急性肾皮质坏死（RCN）相符。PEG与急性肾损伤（AKI）有关，但其确切机制尚不清楚。PEG可生物降解为二甘醇（DEG），这是一种与RCN相关的肾毒性剂。就诊3个月后，患者仍依赖血液透析。
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