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[与妊娠期高血压和子痫前期相关的因素]

[Factors associated with gestational hypertension and preeclampsia].

作者信息

Guzmán-Juárez Wendy, Avila-Esparza Marina, Contreras-Solís Rosa Emma, Levario-Carrillo Margarita

机构信息

Programa de Especialidad en Medicina Familiar, UNAM/IMSS, Unidad de Medicina Familiar Plus 33, Chihuahua, México.

出版信息

Ginecol Obstet Mex. 2012 Jul;80(7):461-6.

Abstract

BACKGROUND

Hypertensive complications in pregnancy are a cause of morbidity and mortality. Previous studies have identified similarities and differences in risk factors of hypertensive complications during pregnancy.

OBJECTIVE

Determine factors associated with gestational hypertension (HTG) and those related to preeclampsia (PEE).

PATIENTS AND METHODS

Case-control study. We included women who completed pregnancy without complications (n=260) and were diagnosed with HTG (n=65) and PEE (n=65). We excluded patients with gestational or pre-pregnancy diabetes, thyroid disease (hypo and hyperthyroidism), autoimmune diseases (lupus erythematosus, rheumatoid arthritis) or diagnosed with heart disease or neuropathy before pregnancy.

RESULTS

There were similarities in the risk factors such as: age over 35 years (OR 8.8, 95% CI 2.91-22.40), previous HTG (OR 64.16 95% CI 13.04-315.57) in case of patients with PEE. But we found a difference in the magnitude of these associations as odds ratios (OR) estimates were higher than in patients with HTG, age over 35 years (OR 3.33, 95% CI 1.03-10.72), and previous HTG (OR 27.27 95% CI 5.60-132.87). First-time pregnant women showed similar associations (OR 3.11 95% CI 1.52-6.38) in case of PEE or HTG (OR 3.14 95% CI 1.65-5.97).

CONCLUSION

There are similarities in risk factors: maternal age--35 years, previous gestational hypertension and first-time pregnancy, for the development of gestational hypertension and preeclampsia.

摘要

背景

妊娠期高血压并发症是发病和死亡的一个原因。既往研究已明确了妊娠期高血压并发症危险因素的异同。

目的

确定与妊娠期高血压(HTG)相关的因素以及与子痫前期(PEE)相关的因素。

患者与方法

病例对照研究。我们纳入了无并发症完成妊娠的女性(n = 260)、被诊断为HTG的女性(n = 65)和被诊断为PEE的女性(n = 65)。我们排除了患有妊娠期或孕前糖尿病、甲状腺疾病(甲状腺功能减退和亢进)、自身免疫性疾病(红斑狼疮、类风湿关节炎)或在妊娠前被诊断患有心脏病或神经病变的患者。

结果

危险因素存在相似之处,例如:对于PEE患者,年龄超过35岁(比值比[OR] 8.8,95%置信区间[CI] 2.91 - 22.40)、既往有HTG(OR 64.16,95% CI 13.04 - 315.57)。但我们发现这些关联的程度存在差异,因为比值比(OR)估计值在PEE患者中高于HTG患者,年龄超过35岁(OR 3.33,95% CI 1.03 - 10.72),既往有HTG(OR 27.27,95% CI 5.60 - 132.87)。初产妇在PEE或HTG情况下显示出相似的关联(PEE时OR 3.11,95% CI 1.52 - 6.38;HTG时OR 3.14,95% CI 1.65 - 5.97)。

结论

在妊娠期高血压和子痫前期的发生中,危险因素存在相似之处:产妇年龄≥35岁、既往妊娠期高血压和初孕。

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