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[血清催乳素、精子数量与活力的相关性。不育男性高催乳素血症的患病率]

[Correlation of serum prolactin, sperm count and motility. Prevalence of hyperprolactinemia in the infertile male].

作者信息

Soler Fernández J M, Caravaca Magariños F, Domínguez Bravo C, Murillo Mirat J, Aparicio Palomino A, Herrera Puerto J

机构信息

Servicio de Urología, Hospital Infanta Cristina, Badajoz, España.

出版信息

Arch Esp Urol. 1990 Oct;43(8):891-5.

PMID:2291683
Abstract

Serum prolactin (PRL) levels were measured in 147 males. All patients had no known tumor, endocrine disorder, or symptoms or signs of hyperprolactinemia. All patients denied taking any medication or agents that could alter PRL levels. Semen analyses revealed 34 patients were normospermic, 69 were oligospermic, 26 were azoospermic, and 18 were purely astenzoospermic. PRL levels for the patient groups were not statistically significantly different. PRL values were higher than the normal ranges in 12.2% of the overall study population. A lower incidence (6.19%) was observed for hyperprolactinemia in the normospermics. These findings are comparable to those described elsewhere. Serum testosterone did not drop significantly in the hyperprolactinemics. Similarly, the FSH and LH values did not change significantly. The possible role of PRL in male infertility and the effect of hyperprolactinemia of varying degrees and etiology on sperm count and motility are discussed.

摘要

对147名男性进行了血清催乳素(PRL)水平检测。所有患者均无已知肿瘤、内分泌紊乱,也无高催乳素血症的症状或体征。所有患者均否认服用过任何可能改变PRL水平的药物或制剂。精液分析显示,34名患者精子正常,69名患者少精子症,26名患者无精子症,18名患者单纯精子活力低下。各患者组的PRL水平无统计学显著差异。在整个研究人群中,12.2%的患者PRL值高于正常范围。正常精子者中高催乳素血症的发生率较低(6.19%)。这些发现与其他地方描述的结果相当。高催乳素血症患者的血清睾酮水平没有显著下降。同样,促卵泡生成素(FSH)和促黄体生成素(LH)值也没有明显变化。本文讨论了PRL在男性不育中的可能作用,以及不同程度和病因的高催乳素血症对精子数量和活力的影响。

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