补体对体液免疫的调节。
Regulation of humoral immunity by complement.
机构信息
Immune Disease Institute and Program in Molecular and Cellular Medicine, Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, 02115 MA, USA.
出版信息
Immunity. 2012 Aug 24;37(2):199-207. doi: 10.1016/j.immuni.2012.08.002.
Abstract
The complement system of innate immunity is important in regulating humoral immunity largely through the complement receptor CR2, which forms a coreceptor on B cells during antigen-induced activation. However, CR2 also retains antigens on follicular dendritic cells (FDCs). Display of antigen on FDCs is critical for clonal selection and affinity maturation of activated B cells. This review will discuss the role of complement in adaptive immunity in general with a focus on the interplay between CR2-associated antigen on B cells with CR2 expressed on FDCs. This latter interaction provides an opportunity for memory B cells to sample antigen over prolonged periods. The cocrystal structure of CR2 with its ligand C3d provides insight into how the complement system regulates access of antigen by B cells with implications for therapeutic manipulations to modulate aberrant B cell responses in the case of autoimmunity.
摘要
补体系统在调节体液免疫中起着重要作用，主要通过补体受体 CR2 实现，该受体在抗原诱导的 B 细胞激活过程中形成 B 细胞的辅助受体。然而，CR2 也能在滤泡树突状细胞（FDC）上保留抗原。FDC 上抗原的展示对于激活 B 细胞的克隆选择和亲和力成熟至关重要。本综述将讨论补体在适应性免疫中的一般作用，重点是 B 细胞上与 CR2 相关的抗原与 FDC 上表达的 CR2 之间的相互作用。这种相互作用为记忆 B 细胞提供了长时间采样抗原的机会。CR2 与其配体 C3d 的共晶结构提供了关于补体系统如何调节 B 细胞获得抗原的见解，这对治疗性操纵具有重要意义，可以调节自身免疫情况下异常 B 细胞反应。
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