Pałgan Krzysztof, Bartuzi Zbigniew
Katedra i Klinika Alergologii, Immunologii Klinicznej i Chorób Wewnętrznych, Collegum Medicum w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu.
Postepy Hig Med Dosw (Online). 2012 Jun 19;66:385-91. doi: 10.5604/17322693.1000901.
Food allergy is now looming as a major health issue with significant implications. In westernized countries, recent reports show a rise in allergic diseases, in particular food allergy. It affects approximately 5-8% of children and 1-5% of adults. Despite this, our current understanding of the immunological and biological mechanisms of food allergy is still incomplete. It is generally believed that food allergy is determined by both genetic and environmental factors. There is some evidence that epigenetic modifications may affect the prevalence of food allergies. This paper discusses the current state of knowledge regarding genetic, epigenetic and environmental factors of food allergy.
食物过敏正逐渐成为一个具有重大影响的主要健康问题。在西方国家,最近的报告显示过敏性疾病有所增加,尤其是食物过敏。它影响着约5%至8%的儿童和1%至5%的成年人。尽管如此,我们目前对食物过敏的免疫和生物学机制的理解仍然不完整。人们普遍认为食物过敏是由遗传和环境因素共同决定的。有证据表明表观遗传修饰可能会影响食物过敏的患病率。本文讨论了关于食物过敏的遗传、表观遗传和环境因素的当前知识状况。