Gensicke H, Engelter S, Bonati L
Neurologie, Stroke Unit, Universitätsspital Basel.
Ther Umsch. 2012 Sep;69(9):523-35. doi: 10.1024/0040-5930/a000325.
About 10 - 15% of all ischaemic strokes are caused by focal atherosclerosis and consecutive narrowing (stenosis) of the internal carotid artery (ICA). Carotid endarterectomy (CEA) - the standard treatment for carotid stenosis - substantially reduces the risk of recurrent stroke among patients who have had ischaemic symptoms such as stroke or transient ischaemic attack attributable to the stenosis. To a smaller extent, CEA also reduces the risk of first stroke in patients with hitherto asymptomatic carotid stenosis. Endovascular treatment techniques, including balloon angioplasty in the initial years and more recently, carotid artery stenting (CAS), have been developed as an alternative to CEA for treating carotid stenosis without necessitating surgery. The present review compares risks and benefits between CAS and CEA summarising the existing evidence derived from randomised controlled trials. Among patients with symptomatic carotid stenosis, CEA is associated with a lower risk of peri-procedural stroke or death than CAS. CAS reduces the risk of peri-procedural myocardial infarction, cranial nerve palsy and access site haematoma compared with CEA. The excess peri-procedural stroke risk associated with CAS appears to be limited to patients older than 70 years while in younger patients, CAS is as safe as CEA. Both treatments are equally effective in preventing recurrent stroke in the first few years following treatment. However, recurrent stenosis appears to be more common after CAS, and longer-term follow-up of ongoing trials should be awaited to investigate whether restenosis might be associated with recurrent stroke. The best treatment approach for patients with asymptomatic carotid stenosis remains to be determined in ongoing clinical trials.
所有缺血性卒中约10%-15%是由局灶性动脉粥样硬化及颈内动脉(ICA)连续性狭窄(狭窄)所致。颈动脉内膜切除术(CEA)——颈动脉狭窄的标准治疗方法——可大幅降低有缺血性症状(如归因于该狭窄的卒中或短暂性脑缺血发作)患者复发性卒中的风险。在较小程度上,CEA也可降低迄今无症状性颈动脉狭窄患者首次发生卒中的风险。血管内治疗技术,包括最初几年的球囊血管成形术以及最近的颈动脉支架置入术(CAS),已被开发作为CEA的替代方法用于治疗颈动脉狭窄而无需手术。本综述比较了CAS和CEA的风险与获益,总结了来自随机对照试验的现有证据。在有症状性颈动脉狭窄患者中,CEA与围手术期卒中或死亡风险低于CAS相关。与CEA相比,CAS降低了围手术期心肌梗死、颅神经麻痹及穿刺部位血肿的风险。与CAS相关的围手术期额外卒中风险似乎仅限于70岁以上患者,而在较年轻患者中,CAS与CEA一样安全。两种治疗在预防治疗后最初几年复发性卒中方面同样有效。然而,CAS后复发性狭窄似乎更常见,有待正在进行试验中的长期随访来研究再狭窄是否可能与复发性卒中相关。无症状性颈动脉狭窄患者的最佳治疗方法仍有待正在进行的临床试验确定。