Targeting the cellular prion protein to treat neurodegeneration.

作者信息

Biasini Emiliano, Harris David A

出版信息

Future Med Chem. 2012 Sep;4(13):1655-8. doi: 10.4155/fmc.12.114.

DOI:10.4155/fmc.12.114

PMID:22924502

Abstract

摘要

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Targeting the cellular prion protein to treat neurodegeneration.

Future Med Chem. 2012 Sep;4(13):1655-8. doi: 10.4155/fmc.12.114.

Upregulation of micro RNA-146a (miRNA-146a), a marker for inflammatory neurodegeneration, in sporadic Creutzfeldt-Jakob disease (sCJD) and Gerstmann-Straussler-Scheinker (GSS) syndrome.

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Localization of A11-reactive oligomeric species in prion diseases.

Histopathology. 2013 Jun;62(7):994-1001. doi: 10.1111/his.12097. Epub 2013 Apr 9.

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Arch Neurol. 2006 Apr;63(4):497-501. doi: 10.1001/archneur.63.4.497.

[Creutzfeldt-Jakob disease(CJD) and Gerstmann-Sträussler-Scheinker syndrome(GSS)].

Nihon Rinsho. 1997 Apr;55(4):972-7.

The epsilon isoform of 14-3-3 protein is a component of the prion protein amyloid deposits of Gerstmann-Sträussler-Scheinker disease.

J Neuropathol Exp Neurol. 2007 Feb;66(2):124-30. doi: 10.1097/nen.0b013e3180302060.

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[Creutzfeldt-Jakob disease and other human transmissible spongiform encephalopathies. Part I].

Psychiatr Pol. 2004 Mar-Apr;38(2):283-96.

Human prion disease and human prion protein disease.

Curr Top Microbiol Immunol. 1996;207:27-34. doi: 10.1007/978-3-642-60983-1_3.

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An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein.

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A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein.

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A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity.

J Neurosci. 2013 Feb 6;33(6):2408-18. doi: 10.1523/JNEUROSCI.3406-12.2013.

Homodimerization as a molecular switch between low and high efficiency PrP C cell surface delivery and neuroprotective activity.

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Targeting the cellular prion protein to treat neurodegeneration.

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