评估复发性流产妇女的精子抗原特异性 T 调节细胞。
Assessment of sperm antigen specific T regulatory cells in women with recurrent miscarriage.
机构信息
Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
出版信息
Early Hum Dev. 2013 Feb;89(2):95-100. doi: 10.1016/j.earlhumdev.2012.08.003. Epub 2012 Aug 25.
BACKGROUND AND AIMS
The prevalence of recurrent miscarriage (RM) is about 1-3% of women; the pathogenesis of RM is not fully understood yet. This study aims to assess the sperm antigen specific regulatory T cells (Treg) in women with RM.
METHODS
A group of women with RM was recruited into this study. The sperm antigen was extracted from the semen samples of each woman's husband. The sperm antigen specific T cell response was assessed by flow cytometry.
RESULTS
Low frequency of sperm specific Tregs and high frequency of T helper (Th)1 cells were detected in RM women as compared with women without RM. The sperm specific Tregs in RM women expressed less Ubc13. Knockdown of Ubc13 from Tregs converted the Tregs to effector T cells.
CONCLUSIONS
Immune deregulation may play an important role in RM.
背景与目的
复发性流产（RM）的患病率约为 1-3%的女性；RM 的发病机制尚未完全阐明。本研究旨在评估 RM 女性的精子抗原特异性调节性 T 细胞（Treg）。
方法
招募了一组 RM 女性参与本研究。从每位女性丈夫的精液样本中提取精子抗原。通过流式细胞术评估精子抗原特异性 T 细胞反应。
结果
与无 RM 的女性相比，RM 女性的精子特异性 Treg 频率较低，辅助性 T 细胞（Th）1 细胞频率较高。RM 女性的精子特异性 Tregs 表达较少的 Ubc13。从 Tregs 敲低 Ubc13 将 Tregs 转化为效应 T 细胞。
结论
免疫失调可能在 RM 中起重要作用。
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