Gao Peng, Tang Xiu-wen, Wang Xiu-jun
Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2012 Jul;41(4):453-63.
Gastrointestinal tract carcinoma is one of the leading causes of cancer-related death in China. Chemoprevention has been considered as a potential approach to control this type of disease. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor that protects cells from oxidative/electrophilic stresses by activating the expression of a battery of cytoprotective genes through the antioxidant response element (ARE). Recently, Nrf2 has emerged as a novel target for chemoprevention. Several natural or synthetic chemicals, which activate Nrf2/ARE signaling pathway, have showed effect in animal models, and promises in many ongoing clinical trials. This review summarizes the recent findings on the regulation of Nrf2/ARE signaling pathway, and the developments in both preclinical and clinical studies.
胃肠道癌是中国癌症相关死亡的主要原因之一。化学预防被认为是控制这类疾病的一种潜在方法。核因子红细胞2相关因子2（Nrf2）是一种对氧化还原敏感的转录因子，它通过抗氧化反应元件（ARE）激活一系列细胞保护基因的表达，从而保护细胞免受氧化/亲电应激。最近，Nrf2已成为化学预防的新靶点。几种激活Nrf2/ARE信号通路的天然或合成化学物质在动物模型中已显示出效果，并且在许多正在进行的临床试验中也展现出前景。本综述总结了关于Nrf2/ARE信号通路调控的最新研究结果，以及临床前和临床研究的进展。
