AKT1 作为与丹麦和德国 90 岁及以上老人长寿相关的基因，其复制未能成功。
AKT1 fails to replicate as a longevity-associated gene in Danish and German nonagenarians and centenarians.
机构信息
Epidemiology, Institute of Public Health, University of Southern Denmark, Odense C, Denmark.
出版信息
Eur J Hum Genet. 2013 May;21(5):574-7. doi: 10.1038/ejhg.2012.196. Epub 2012 Aug 29.
In addition to APOE and FOXO3, AKT1 has recently been suggested as a third consistent longevity gene, with variants in AKT1 found to be associated with human lifespan in two previous studies. Here, we evaluated AKT1 as a longevity-associated gene across populations by attempting to replicate the previously identified variant rs3803304 as well as by analyzing six additional AKT1 single-nucleotide polymorphisms, thus capturing more of the common variation in the gene. The study population was 2996 long-lived individuals (nonagenarians and centenarians) and 1840 younger controls of Danish and German ancestry. None of the seven SNPs tested were significantly associated with longevity in either a case-control or a longitudinal setting, although a supportive nominal indication of a disadvantageous effect of rs3803304 was found in a restricted group of Danish centenarian men. Overall, our results do not support AKT1 as a universal longevity-associated gene.
除了 APOE 和 FOXO3，AKT1 最近也被认为是第三个一致的长寿基因，先前的两项研究发现 AKT1 中的变异与人类寿命有关。在这里，我们通过尝试复制先前确定的变体 rs3803304 以及分析另外六个 AKT1 单核苷酸多态性，来评估 AKT1 在不同人群中作为长寿相关基因的作用，从而捕获基因中更多常见的变异。研究人群是 2996 名长寿个体（90 岁以上的人和百岁老人）和 1840 名丹麦和德国血统的年轻对照者。在病例对照或纵向研究中，没有一个测试的 7 个单核苷酸多态性与长寿显著相关，尽管在一个丹麦百岁男性的受限群体中发现了 rs3803304 不利影响的支持性名义指示。总的来说，我们的结果不支持 AKT1 作为一个普遍的长寿相关基因。
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