哮喘中的气道平滑肌：仅仅是支气管扩张的靶点吗？
Airway smooth muscle in asthma: just a target for bronchodilation?
机构信息
University of Sydney, Discipline of Pharmacology and Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, 2006, Australia.
出版信息
Clin Chest Med. 2012 Sep;33(3):543-58. doi: 10.1016/j.ccm.2012.05.002. Epub 2012 Jul 11.
Abstract
Airway smooth muscle (ASM) has long been recognized as the main cell type responsible for bronchial hyperresponsiveness. It has, thus, been considered as a target for bronchodilation. In asthma, however, there is a complex relationship between ASM and inflammatory cells, such as mast cells and T lymphocytes. Moreover, the increased ASM mass in asthmatic airways is one of the key features of airway remodeling. This article aims to review the main concepts about the 3 possible roles of ASM in asthma: (1) contractile tone, (2) inflammatory response, and (3) remodeling.
摘要
气道平滑肌（ASM）一直被认为是导致支气管高反应性的主要细胞类型。因此，ASM 一直被视为支气管扩张的靶点。然而，在哮喘中，ASM 与炎症细胞（如肥大细胞和 T 淋巴细胞）之间存在复杂的关系。此外，哮喘气道中 ASM 质量的增加是气道重塑的关键特征之一。本文旨在综述 ASM 在哮喘中可能发挥的 3 种作用的主要概念：（1）收缩张力，（2）炎症反应，和（3）重塑。
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