Leskowitz E
Department of Psychiatry, VA Outpatient Clinic, Boston, MA 02108.
Med Hypotheses. 1990 Nov;33(3):155-8. doi: 10.1016/0306-9877(90)90165-b.
Seasonal Affective Disorder is a psychiatric disorder whose pathophysiology and clinical presentation are poorly understood. By applying the ancient paradigm of yoga psychology to this subject, new understandings of the syndrome emerge regarding the possible role of the pineal gland, the clinical presentation of the syndrome, and the possible mechanism of action of phototherapy. The energy depletion model presented here ties together such diverse elements as: dose-response aspects of phototherapy, anergia as a primary symptom of SAD, 'spring fever', myofascial pain disorder, the anti-gonadotrophic effect of melatonin, and pineal supersensitivity in bipolar patients. Clinical predictions are made, and simple research protocols are suggested which can directly test the hypotheses generated by this paradigm.
季节性情感障碍是一种病理生理学和临床表现尚未得到充分了解的精神疾病。通过将古老的瑜伽心理学范式应用于这一主题，对于该综合征的可能作用、综合征的临床表现以及光疗法的可能作用机制产生了新的认识。这里提出的能量耗竭模型将多种不同的因素联系在一起，如：光疗法的剂量反应方面、无活力作为季节性情感障碍的主要症状、“春困”、肌筋膜疼痛障碍、褪黑素的抗促性腺激素作用以及双相情感障碍患者的松果体超敏反应。做出了临床预测，并提出了简单的研究方案，可直接检验该范式所产生的假设。
