基因组对抗寄生虫。

Genomes against parasites.

出版信息

Nat Genet. 2012 Sep;44(9):961. doi: 10.1038/ng.2407.

Abstract

Whereas once it was only possible to generate reference genome sequences one at a time, it is now feasible to design genomic experiments to maximize functional comparisons and contrasts among many genomes. Investigating the diversity of a number of related parasite genomes and their transcriptomes in multiple contexts increasingly shows us ways to intervene in the ecological and evolutionary strategies of pathogens.

摘要

以前，一次只能生成一个参考基因组序列，而现在则可以设计基因组实验，以最大限度地对许多基因组进行功能比较和对比。在多种环境下研究多个相关寄生虫基因组及其转录组的多样性，正越来越多地为我们提供干预病原体生态和进化策略的方法。