Londino Iii Aldo V, Miles Brett A
Department of Otolaryngology, The Mount Sinai Hospital, New York, NY 10029, USA.
J Skin Cancer. 2012;2012:742303. doi: 10.1155/2012/742303. Epub 2012 Aug 15.
Merkel cell carcinoma (MCC) is an uncommon neuroendocrine malignancy with a propensity for the head and neck. It typically presents asymptomatically in elderly Caucasians and is characterized by early local and regional spread. There is currently limited data on the appropriate algorithm for treatment of MCC. However, multimodal therapy with wide surgical excision with or without radiation therapy has become standard of care. The location of the primary tumor and intensive adjuvant therapy is often required, provides a challenge to the reconstructive head and neck surgeon. Occasionally, free tissue transfer reconstructive techniques are employed in the reconstruction of MCC defects. This paper will discuss the role of free tissue transfer as a reconstructive option after surgery for advanced head and neck MCC.
默克尔细胞癌(MCC)是一种罕见的神经内分泌恶性肿瘤,好发于头颈部。它通常在老年白种人中无症状出现,其特点是早期局部和区域扩散。目前关于MCC合适治疗方案的相关数据有限。然而,采用广泛手术切除并结合或不结合放射治疗的多模式治疗已成为标准治疗方法。原发肿瘤的位置以及通常需要的强化辅助治疗,给头颈重建外科医生带来了挑战。偶尔,在MCC缺损的重建中会采用游离组织移植重建技术。本文将探讨游离组织移植在晚期头颈部MCC手术后作为一种重建选择的作用。