Department of Radiology, School of Medicine, Iwate Medical University, 19-1 Uchimaru, Morioka 020-8505, Japan.
Jpn J Radiol. 2012 Nov;30(9):752-61. doi: 10.1007/s11604-012-0122-3. Epub 2012 Sep 1.
The purpose of this study was to show the effectiveness of combining intra-arterial infusion and systemic chemotherapy with concurrent radiotherapy for treatment of stage IV mandibular gingival cancer.
A total of 23 patients with mandibular gingival cancer were treated with either docetaxel by intra-arterial infusion followed by systemic chemoradiotherapy with cisplatinum and 5-fluorouracil as a monthly regimen, or with docetaxel and cisplatinum by intra-arterial infusion followed by systemic chemoradiotherapy with 5-fluorouracil as a weekly or biweekly regimen. Tumor responses, locoregional control, overall survival, disease-specific survival, and adverse events were evaluated.
Of the 23 patients enrolled in the study, 22 completed the treatment. With regard to clinical stages, 82 % were diagnosed as IVA and 18 % IVB. Complete and partial response was observed in 82 and 18 %, respectively. Five-year overall survival, disease-specific survival, and locoregional control were 51, 70, and 72 %, respectively. No statistically significant difference was seen between the monthly regimen and the weekly plus biweekly regimen, although the latter resulted in longer survival and 88 % control.
Combined intra-arterial infusion and systemic chemoradiotherapy may be an effective treatment for patients with stage IV mandibular gingival cancer.
本研究旨在展示动脉内输注和全身化疗联合同步放化疗治疗 IV 期下颌牙龈癌的疗效。
共 23 例下颌牙龈癌患者接受多西紫杉醇动脉内输注，随后行顺铂和 5-氟尿嘧啶全身化疗作为每月方案，或接受多西紫杉醇和顺铂动脉内输注，随后行 5-氟尿嘧啶全身化疗每周或每两周方案。评估肿瘤反应、局部区域控制、总生存期、疾病特异性生存期和不良事件。
在研究中纳入的 23 例患者中，22 例完成了治疗。就临床分期而言，82%被诊断为IVA，18%为IVB。分别观察到完全缓解和部分缓解率为 82%和 18%。5 年总生存率、疾病特异性生存率和局部区域控制率分别为 51%、70%和 72%。虽然后者的生存时间更长，控制率为 88%，但每月方案和每周加每两周方案之间没有统计学差异。
动脉内输注联合全身化疗联合放化疗可能是治疗 IV 期下颌牙龈癌的有效方法。
