通过 DNA 复制保持：组蛋白修饰或修饰剂？
Holding on through DNA replication: histone modification or modifier?
出版信息
Cell. 2012 Aug 31;150(5):875-7. doi: 10.1016/j.cell.2012.08.006.
PMID:22939615
Abstract
Histone methylation is widely believed to contribute to epigenetic inheritance by persevering through DNA replication and subsequently templating methylation of daughter chromosome regions. However, a report in this issue (Petruk et al.) suggests that chromatin association of the methytransferase complexes themselves persists through replication and re-establishes histone methylation.
摘要
组蛋白甲基化被广泛认为通过在 DNA 复制过程中保持稳定，随后模板化女儿染色体区域的甲基化，从而有助于表观遗传遗传。然而，本期杂志中的一篇报道（Petruk 等人）表明，甲基转移酶复合物本身与染色质的关联在复制过程中得以保留，并重新建立组蛋白甲基化。
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