Xu Wen, Zhu Yan-hua, Yan Jin-hua, Yang Xu-bin, Zhang Guo-chao, Zeng Long-yi, Weng Jian-ping
Department of Endocrinology, Sun Yat-sen University, Guangzhou, China.
Zhonghua Yi Xue Za Zhi. 2012 Jul 10;92(26):1820-3.
To decipher the characteristics of real-life glucose profiles in normal glucose tolerance (NGT) persons by continuous glucose monitoring system (CGMS).
Forty NGT subjects confirmed by oral glucose tolerance test (OGTT) completed a 3-day period of glucose monitoring via CGMS.
The values of 24 h mean blood glucose (MBG), standard deviation of MBG (SDBG), mean amplitude of glycemic excursions (MAGE), largest amplitude of glycemic excursions (LAGE) and means of daily differences (MODD) were 6.0 ± 0.7, 0.9 ± 0.1, 1.9 ± 0.8, 2.9 ± 1.4 and 1.1 ± 0.1 mmol/L respectively. Two of them experienced asymptomatic hypoglycemia defined as glucose concentration < 2.8 mmol/L. And 72.5% (29/40) subjects reached glucose concentrations > 7.8 mmol/L for 5.2 ± 4.6 hours. In addition to higher glucose concentration (FPG: 5.0 ± 0.4 vs 4.8 ± 0.3 mmol/L, MBG: 6.4 ± 0.7 vs 5.7 ± 0.5 mmol/L), the subjects with glucose concentrations > 7.8 mmol/L showed more dramatic glucose excursion represented by higher SDBG (1.1 ± 0.3 vs 0.6 ± 0.2 mmol/L), MAGE (2.3 ± 1.1 vs 1.1 ± 0.3 mmol/L), LAGE (3.3 ± 1.2 vs 2.0 ± 1.0 mmol/L) and MODD (1.2 ± 0.4 vs 0.9 ± 0.3 mmol/L) versus those with glucose concentrations within 7.8 mmol/L.
CGMS provides more detailed information of real-life glucose profiles in NGT subjects. And 72.5% NGT subjects in the present study spent a considerable amount of time at pre-diabetic or even diabetic glucose levels characterized by more predominant glucose excursion.
通过连续血糖监测系统（CGMS）解读正常糖耐量（NGT）人群的实际血糖特征。
40名经口服葡萄糖耐量试验（OGTT）确诊的NGT受试者通过CGMS完成了为期3天的血糖监测。
24小时平均血糖（MBG）、MBG标准差（SDBG）、血糖波动平均幅度（MAGE）、血糖波动最大幅度（LAGE）及每日血糖差值均值（MODD）分别为6.0±0.7、0.9±0.1、1.9±0.8、2.9±1.4及1.1±0.1 mmol/L。其中2人经历了定义为血糖浓度<2.8 mmol/L的无症状低血糖。72.5%（29/40）的受试者血糖浓度>7.8 mmol/L的时长为5.2±4.6小时。除血糖浓度较高外（空腹血糖：5.0±0.4 vs 4.8±0.3 mmol/L，MBG：6.4±0.7 vs 5.7±0.5 mmol/L），血糖浓度>7.8 mmol/L的受试者相较于血糖浓度在7.8 mmol/L以内的受试者，其血糖波动更为显著，表现为更高的SDBG（1.1±0.3 vs 0.6±0.2 mmol/L）、MAGE（2.3±1.1 vs 1.1±0.3 mmol/L）、LAGE（3.3±1.2 vs 2.0±1.0 mmol/L）及MODD（1.2±0.4 vs 0.9±0.3 mmol/L）。
CGMS提供了NGT受试者实际血糖特征的更详细信息。本研究中72.5%的NGT受试者在糖尿病前期甚至糖尿病血糖水平停留了相当长的时间，其血糖波动更为突出。
