Zhernosekov D D, Iusova E I, Grinenko T V
Ukr Biokhim Zh (1999). 2012 Jul-Aug;84(4):5-19.
The article deals with the data concerning structural peculiarities of plasminogen/plasmin molecule, which define the specificity of intermolecular interactions and provide the variety of its biological functions. The main principles of the modern classification of plasminogen receptors and factors, which modulate their expression, have been presented. We have considered the mechanisms regulating both plasmin formation and activity on the surface of cells, fibrin and proteins of extracellular matrix. The data of previous investigators and our own results, concerning the influence of plasminogen/plasmin on platelet aggregation induced by different agonists, have been summarized. The participation of plasminogen/plasmin in atherogenesis and angiogenesis mediated by endotheliocyte receptors has been discussed. Special attention was given to plasminogen/plasmin proinflammatory function, which is realized by regulatory processes of activation, secretion, migration and apoptosis of monocytes and macrophages.
本文论述了有关纤溶酶原/纤溶酶分子结构特点的数据，这些特点决定了分子间相互作用的特异性并赋予其多种生物学功能。文中介绍了纤溶酶原受体及调节其表达的因子的现代分类主要原则。我们探讨了细胞表面、纤维蛋白和细胞外基质蛋白上纤溶酶形成和活性的调节机制。总结了先前研究者的数据以及我们自己关于纤溶酶原/纤溶酶对不同激动剂诱导的血小板聚集影响的结果。讨论了纤溶酶原/纤溶酶在内皮细胞受体介导的动脉粥样硬化和血管生成中的作用。特别关注了纤溶酶原/纤溶酶的促炎功能，该功能通过单核细胞和巨噬细胞的激活、分泌、迁移和凋亡调节过程得以实现。
