Section of Rheumatology, Medizinische Klinik und Poliklinik III, University Hospital, Sigmund-Freud-Strasse 25, 53127, Bonn, Germany.
Curr Rheumatol Rep. 2012 Dec;14(6):583-8. doi: 10.1007/s11926-012-0289-8.
Arthritis is characterized by pain and inflammation. Recently, attention has been focused on nerve-growth factor (NGF), a neurotrophin that is a key regulator of peripheral nociception because it mediates overexpression of proinflammatory neuron-derived molecules such as substance P, serotonin, and calcitonin gene-related peptide. Antibodies have been generated for NGF and its receptor that are effective in reducing pain in preclinical pain models, and clinical trials in patients with advanced knee and hip osteoarthritis and low-back pain. Results show pain reduction is rapid and sustained. Adverse events with anti-NGF included transient paraesthesia and edema, rapidly progressive OA, and, in a small number of patients treated with both anti-NGF and nonsteroidal anti-inflammatory drugs, osteonecrosis. Inhibition of the NGF-stimulated nociceptive pathway seems to be effective; however, the adverse effects require further investigation.
关节炎的特征为疼痛和炎症。近来，人们对神经生长因子（NGF）越来越关注，NGF 是一种神经营养因子，是外周伤害感受的关键调节因子，因为它介导促炎神经元衍生分子（如 P 物质、血清素和降钙素基因相关肽）的过表达。已经针对 NGF 及其受体生成了抗体，这些抗体在临床前疼痛模型中可有效减轻疼痛，并且在患有晚期膝和髋骨关节炎和腰痛的患者中进行了临床试验。结果表明，疼痛减轻迅速且持久。抗 NGF 的不良反应包括短暂性感觉异常和水肿、快速进展性 OA，以及在少数同时接受抗 NGF 和非甾体抗炎药治疗的患者中出现骨坏死。抑制 NGF 刺激的伤害感受途径似乎是有效的；然而，不良反应需要进一步研究。
