Shi Weiwei, Yang Bo, Li Xiaoyan, Sun Shengjie, Wang Lijie, Jiao Shunchang
Department of Oncology, PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.
Tumour Biol. 2012 Dec;33(6):2379-83. doi: 10.1007/s13277-012-0501-5. Epub 2012 Sep 5.
Lysyl oxidase (LOX) is a copper-dependent amine oxidase that plays important roles in development and homeostasis of the lungs. The aim of this study was to investigate whether polymorphisms in the LOX gene were associated with susceptibility to nonsmall cell lung cancer (NSCLC). We sequenced the promoter region of LOX gene and tested the previously reported polymorphism 473 G/A in the Han Chinese population. A novel polymorphism, -22 G/C, was identified in the promoter region of LOX. However, it did not show any correlation with NSCLC. Frequencies of the 473AA genotype and 473A allele were significantly higher in the NSCLC cases than in control group (p = 0.004 and p = 0.006, respectively). Further, our results showed that survival time of NSCLC patients with 473AA genotype was significantly shorter compared to the cases carrying 473 G allele (20.0 months vs. 28.0 months, p = 0.011). These data indicate that LOX 473 G/A polymorphism is associated with increased risk of NSCLC and can be a prognostic predictor for this disease.
赖氨酰氧化酶（LOX）是一种依赖铜的胺氧化酶，在肺的发育和内环境稳定中发挥重要作用。本研究的目的是调查LOX基因多态性是否与非小细胞肺癌（NSCLC）的易感性相关。我们对LOX基因的启动子区域进行了测序，并在汉族人群中检测了先前报道的473 G/A多态性。在LOX的启动子区域鉴定出一种新的多态性，即-22 G/C。然而，它与NSCLC没有任何相关性。NSCLC病例中473AA基因型和473A等位基因的频率显著高于对照组（分别为p = 0.004和p = 0.006）。此外，我们的结果显示，与携带473 G等位基因的病例相比，473AA基因型的NSCLC患者的生存时间显著缩短（20.0个月对28.0个月，p = 0.011）。这些数据表明，LOX 473 G/A多态性与NSCLC风险增加相关，并且可以作为该疾病的预后预测指标。
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