Tajima Yasutaka, Mito Yasunori, Yanai Mituru, Fukazawa Yu-Ichiro
Department of Neurology, Brain Health Center, Sapporo City General Hospital, Sapporo, Japan.
BMJ Case Rep. 2012 Sep 3;2012:bcr2012006522. doi: 10.1136/bcr-2012-006522.
A 64-year-old man suffering from diabetes mellitus and chronic renal failure was admitted to our hospital because of consciousness disturbance and parkinsonism. Cranial MRI showed very characteristic features involving the bilateral basal ganglia. Subsequent postmortem examinations demonstrated demyelination in the affected areas. These myelin destruction patterns were quite similar to those of central pontine myelinolysis. However, rapid correction of hyponatraemia was ruled out in this patient. Therefore, a new demyelinating brain disease associated with diabetes mellitus and chronic renal failure was suggested.
一名64岁患有糖尿病和慢性肾衰竭的男性因意识障碍和帕金森综合征入住我院。头颅磁共振成像显示双侧基底节区有非常典型的特征。随后的尸检显示病变区域存在脱髓鞘。这些髓鞘破坏模式与脑桥中央髓鞘溶解症的模式非常相似。然而，该患者排除了低钠血症的快速纠正。因此，提示存在一种与糖尿病和慢性肾衰竭相关的新型脱髓鞘性脑病。
