Thompson J W, Rosenthal P, Camilon F S
Department of Surgery, Children's Hospital of Los Angeles, CA.
Arch Otolaryngol Head Neck Surg. 1990 Jan;116(1):46-8. doi: 10.1001/archotol.1990.01870010050015.
Bilateral vocal cord paralysis and absent laryngeal sensation are previously unrecognized sequelae for Reye's syndrome, a severe acute encephalopathy in children. Four patients were seen at varying periods ranging from 2 weeks to 5 years after their diagnosis of an episode of severe Reye's syndrome over a 20-year period at the Children's Hospital of Los Angeles (Calif). All of the patients had bilateral true vocal cord paralysis with absent laryngeal sensitivity that was documented at endoscopy. As many as 50% of survivors of severe Reye's syndrome have breathy voices or aphonia. It is suggested that some of these children may have vocal cord dysfunction that is not the result of intubation, and are at risk for aspiration and its dangerous sequelae. A vagal nuclear injury is theorized to explain the sensory motor dysfunction of the larynx in these children.
双侧声带麻痹和喉感觉缺失是瑞氏综合征此前未被认识到的后遗症，瑞氏综合征是一种发生于儿童的严重急性脑病。在洛杉矶儿童医院（加利福尼亚州）20年期间，有4例患者在诊断为严重瑞氏综合征发作后的不同时期就诊，时间跨度从2周到5年不等。所有患者均有双侧真性声带麻痹且在内镜检查中证实喉感觉缺失。严重瑞氏综合征的幸存者中多达50%有呼吸声或失音。提示这些儿童中的一些可能存在并非插管所致的声带功能障碍，并有发生误吸及其危险后遗症的风险。理论上认为迷走神经核损伤可解释这些儿童的喉部感觉运动功能障碍。
