Université Catholique de Louvain, Institute of Neurosciences, Unit of Otorhinolaryngology, Cliniques Universitaires St Luc, Brussels, Belgium.
Otolaryngol Head Neck Surg. 2012 Dec;147(6):1136-41. doi: 10.1177/0194599812459704. Epub 2012 Sep 5.
Several prognostic factors influencing the recovery from olfactory dysfunction have been described. The aim of this study was to investigate whether olfactory bulb volume could be used as a new predictor of olfactory recovery in postinfectious and posttraumatic olfactory loss.
Cohort study; Level of evidence, 4. Setting Tertiary university clinic, department of otolaryngology.
A cohort of 60 patients with postinfectious (n = 28) and posttraumatic olfactory loss (n = 32) was investigated. Assessment of olfactory function was performed using orthonasal (Sniffin' Sticks test) and retronasal psychophysical olfactory tests, at the time of the diagnosis (t1) and 15 months later (t2). All patients were examined on 3 tesla magnetic resonance imaging, and the olfactory bulbs volume was assessed using planimetric contouring at the time of the diagnosis (t1).
Recovery rate was 25% in patients with posttraumatic olfactory loss and 36% in patients with postinfectious olfactory loss. There was a correlation between both orthonasal and retronasal olfactory testing and the initial measurement of the total olfactory bulb volume. In addition, we observed a significant correlation between changes in olfactory functions and initial measurement of the total olfactory bulb volume, with larger volumes relating to higher improvement of olfactory function. Finally, we found that none of the patients with a total olfactory bulb volume of 40 mm(3) or less exhibited recovery of olfactory function.
Olfactory bulb volume seems to be a predictor of olfactory recovery in patients with postinfectious and posttraumatic olfactory loss.
已经描述了影响嗅觉功能恢复的几个预后因素。本研究旨在探讨嗅球体积是否可作为预测感染后和创伤后嗅觉丧失嗅觉恢复的新指标。
队列研究；证据水平，4 级。设置三级大学诊所，耳鼻喉科。
对 60 例感染后（n = 28）和创伤后嗅觉丧失（n = 32）患者进行了研究。嗅觉功能评估采用鼻（Sniffin' Sticks 测试）和鼻后嗅觉心理物理测试，在诊断时（t1）和 15 个月后（t2）进行。所有患者均在 3T 磁共振成像检查，在诊断时（t1）使用平面轮廓法评估嗅球体积。
创伤后嗅觉丧失患者的恢复率为 25%，感染后嗅觉丧失患者的恢复率为 36%。在鼻前和鼻后嗅觉测试与嗅球总容积的初始测量之间存在相关性。此外，我们观察到嗅觉功能的变化与嗅球总容积的初始测量之间存在显著相关性，较大的体积与嗅觉功能的改善程度较高相关。最后，我们发现总嗅球体积为 40mm³或更小的患者均未恢复嗅觉功能。
嗅球体积似乎是预测感染后和创伤后嗅觉丧失患者嗅觉恢复的指标。
