Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
ASAIO J. 2012 Sep-Oct;58(5):514-21. doi: 10.1097/MAT.0b013e318260c5bb.
Hemodiafiltration (HDF) has been reported to deliver better dialysis outcomes in patients with end-stage renal disease. Technical advances now allow online-based HDF to be used on a clinical basis. However, HDF is being performed at a limited rate because of the requirement of exogenous fluid infusion, which causes safety and cost issues. Therefore, various modifications on HDF strategies have been devised to achieve the HDF without exogenous fluid infusion, which can be achieved by spontaneous fluid reinfusion. In this article, substitution-free HDF strategies are reviewed in detail, with specific attention to technical aspects of the methodology, in vivo and in vitro efficacies, and applicability to clinical use.
血液透析滤过 (HDF) 已被报道可改善终末期肾病患者的透析效果。技术进步现在允许基于在线的 HDF 在临床基础上使用。然而，由于需要外源性液体输注，HDF 的应用率有限，这会引发安全和成本问题。因此，人们设计了各种 HDF 策略的改进方法，以实现无需外源性液体输注的 HDF，这可以通过自发的液体再输注来实现。本文详细回顾了无置换 HDF 策略，特别关注方法的技术方面、体内和体外疗效以及在临床应用中的适用性。
