Institute of Mathematics and Computer Science, University of São Paulo, São Carlos, SP, Brazil.
Neural Netw. 2012 Nov;35:40-5. doi: 10.1016/j.neunet.2012.08.002. Epub 2012 Aug 21.
It has been revealed that the network of excitable neurons via attractive coupling can generate spikes under stimuli of subthreshold signals with disordered phases. In this paper, we explore the firing activity induced by phase disorder in excitable neuronal networks consisting of both attractive and repulsive coupling. By increasing the fraction of repulsive coupling, we find that, in the weak coupling strength case, the firing threshold of phase disorder is increased and the system response to subthreshold signals is decreased, indicating that the effect of inducing neuron firing by phase disorder is weakened with repulsive coupling. Interestingly, in the large coupling strength case, we see an opposite situation, where the coupled neurons show a rather large response to the subthreshold signals even with small phase disorder. The latter case implies that the effect of phase disorder is enhanced by repulsive coupling. A system of two-coupled excitable neurons is used to explain the role of repulsive coupling on phase-disorder-induced firing activity.
已经揭示，通过吸引耦合的可激神经元网络可以在具有无序相位的亚阈值信号刺激下产生尖峰。在本文中，我们研究了由吸引和排斥耦合组成的可激神经元网络中由相位失序引起的放电活动。通过增加排斥耦合的分数，我们发现，在弱耦合强度的情况下，相位失序的点火阈值增加，系统对亚阈值信号的响应减小，这表明相位失序诱导神经元点火的效果随着排斥耦合的增加而减弱。有趣的是，在大耦合强度的情况下，我们看到了相反的情况，即耦合神经元即使在小的相位失序下也对亚阈值信号表现出相当大的响应。后一种情况意味着，排斥耦合增强了相位失序的作用。使用两耦合可激神经元系统来解释排斥耦合对相位失序诱导点火活动的作用。
