1st Department of Medicine, School of Medicine, University of Pecs, Pecs, Hungary.
Clin Hemorheol Microcirc. 2013;53(1-2):81-96. doi: 10.3233/CH-2012-1578.
Platelets play an important role both in normal hemostasis and in pathological thrombus formation. Several large-scale clinical studies have proved that the inhibition of platelet aggregation results in a significant decrease in mortality and morbidity of ischemic atherothrombotic events, thus antiplatelet therapy became a key pharmacological method in prevention and treatment of such cardiovascular, cerebrovascular and peripheral arterial diseases. The present paper aims to give a brief overview of the most important antiplatelet drugs, their mechanism of action and their recommended usage in cardiovascular diseases. We also discuss possible methods to monitor the effectiveness of therapy and possible causes of therapeutic failure.
血小板在正常止血和病理性血栓形成中都起着重要作用。几项大规模的临床研究已经证明，抑制血小板聚集可显著降低缺血性动脉粥样硬化血栓事件的死亡率和发病率，因此抗血小板治疗成为预防和治疗此类心血管、脑血管和外周动脉疾病的关键药理学方法。本文旨在简要概述最重要的抗血小板药物、它们的作用机制以及在心血管疾病中的推荐用法。我们还讨论了监测治疗效果的可能方法和治疗失败的可能原因。
